Invitrogen™ Cerebral Protein 1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5120751

Catalog No. PIPA5120751

Description

Positive test controls include: Mouse kidney, Mouse spleen, Rat kidney, Rat thymus. Immunogen sequence: GPPCSDSEEE VERKKKCHKQ ALVGSDSAED EKRKRKCQKH APINSAQHLD NVDQTGPKAW KGSTTNDPPK QSPGSTSPKP PHTLSRKQWR NRQKNKRRCK N.

Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.

Specifications

• Antigen: Cerebral Protein 1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Rrp8
• Gene Alias: 1500003O22Rik; 2900001K19Rik; AW538116; Cerebral protein 1; cerebral protein 1 homolog; HUCE1; hucep1; hucep-1; KIAA0409; NML; Nucleomethylin; RGD1308302; ribosomal RNA processing 8, methyltransferase, homolog (yeast); ribosomal RNA-processing protein 8; Rrp8; RRP-8; RRP8 methyltransferase homolog
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 101867, 23378, 308911
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 1.104 mg/mL
• Formulation: PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
• Gene Accession No.: O43159, Q5U4F0, Q9DB85
• Gene Symbols: Rrp8
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 100-200 of human RRP8 (NP_056139.1).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG