Invitrogen™ CFC1B/CFC1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA575660

Catalog No. PIPA575660

Description

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Cryptic is a 224 amino acid member of the epidermal growth factor-Cripto-1/ FRL1/cryptic family that consists of extracellular and cell-associated proteins which function as co-receptors for the transforming growth factor b subfamily of proteins. Cryptic is involved in the appropriate establishment of the left-right axis of the organism, and it may play a role in the development of mesoderm and/or neural patterning during gastrulation. Loss-of-function mutations in CFC1, the gene encoding for Cryptic, are associated with human left-right laterality defects. Defects in CFC1 also cause visceral heterotaxy (HTX2), an autosomal disease characterized by a variable group of congenital anomalies that include complex cardiac malformations such as conotruncal heart malformations that may lead to cardiac outflow tract defects, pulmonary atresia, double-outlet right ventricle, truncus arteriosus communis and aortic arch anomalies.

Specifications

• Antigen: CFC1B/CFC1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CFC1B
• Gene Alias: AV265756; b2b970Clo; CFC1; CFC1B; cripto, FRL-1, cryptic family 1; cripto, FRL-1, cryptic family 1B; cryptic; Cryptic family protein 1; cryptic family protein 1B; Cryptic protein; DTGA2; heterotaxy 2 (autosomal dominant); HTX2; RGD1562188
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 12627, 501121, 55997, 653275
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P0CG36, P0CG37, P97766
• Gene Symbols: CFC1, CFC1B
• Immunogen: Synthetic peptide corresponding to residues in Human CFC1B/CFC1.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov