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Description
This gene is a member of the Regulator of Complement Activation (RCA) gene cluster and encodes a protein with twenty short concensus repeat (SCR) domains. This protein is secreted into the bloodstream and has an essential role in the regulation of complement activation, restricting this innate defense mechanism to microbial infections. Mutations in this gene have been associated with hemolytic-uremic syndrome (HUS) and chronic hypocomplementemic nephropathy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq]
Specifications
Specifications
| Antigen | CFH |
| Applications | ELISA, Flow Cytometry, Immunohistochemistry (PFA fixed), Immunoprecipitation, Western Blot |
| Classification | Monoclonal |
| Clone | OX-24 |
| Conjugate | Unconjugated |
| Description | Mouse monoclonal antibody raised against human CFH. |
| Dilution | ELISA Flow Cytometry Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (20 ug/mL) Immunoprecipitation Western Blot The optimal working dilution should be determined by the end user. |
| Formulation | In PBS (0.02% sodium azide). |
| Gene Alias | ARMD4/ARMS1/CFHL3/FH/FHL1/HF/HF1/HF2/HUS/MGC88246 |
| Gene Symbols | CFH |
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