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Invitrogen™ CFHR1/CFHR2 Monoclonal Antibody (JHD-7.10.1)
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Catalog No. PIMA533357
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100 μg
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Catalog No. Quantity
PIMA533357 100 μg
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Catalog No. PIMA533357 Supplier Invitrogen™ Supplier No. MA533357
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Description

Mouse Monoclonal Antibody

Product is supplied at 1 mL (100 μL/mL). Due to a high degree of amino acid sequence homology this product is cross-reactive with both CFHR1 and 2.

In humans the complement factor H protein family consists of complement factor H, the factor H-like protein 1 and five factor H-related proteins termed 1 to 5. All members of this group are expressed primarily in the liver and subsequently secreted into plasma. The secreted forms of these proteins are composed exclusively of repetitive protein domains termed short consensus repeats (SCR). The CFHR1 protein is composed of five SCR domains and circulates in plasma as two differentially glycosylated isoforms (37 kDa and 43 kDa). CFHR-2 is composed of four SCRs and is present in human plasma in a non-glycosylated form (24 kDa) and a glycosylated form of 29 kDa. So far the biological functions of both CFHR-1 and CFHR-2 proteins are poorly understood, however recent studies have shown that CFHR1 is a complement regulator that blocks C5 convertase activity as well as assembly and membrane insertion of the terminal components. Moreover, genetic variations in the CFHR1 gene are associated with several diseases such as atypical hemolytic uremic syndrome and age-related macular degeneration.
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Specifications

Antigen CFHR1/CFHR2
Applications ELISA
Classification Monoclonal
Clone JHD-7.10.1
Concentration 100 μg/mL
Conjugate Unconjugated
Formulation PBS with 0.1% BSA and 0.02% sodium azide
Gene CFHR2
Gene Accession No. P36980, Q03591
Gene Alias CFHL; CFHL1; CFHL1P; CFHL2; CFHR1; CFHR1P; CFHR2; complement factor H related 1; complement factor H related 2; complement factor H-related 1 pseudogene; complement factor H-related 2; complement factor H-related protein 1; Complement factor H-related protein 2; DDESK59; factor H-related gene 2; FHR1; FHR-1; FHR2; FHR-2; H factor (complement)-like 1; H factor (complement)-like 2; H factor (complement)-like 3; h factor-like 3; H factor-like protein 1; h factor-like protein 2; H36; H36-1; H36-2; H-factor-like 1; HFL1; HFL2; HFL3
Gene Symbols CFHR1, CFHR2
Host Species Mouse
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3078, 3080
Target Species Human
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG1
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