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Invitrogen™ CFHR1/CFHR2 Monoclonal Antibody (JHD-7.10.1)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA533357

Catalog No. PIMA533357


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Description

Description

Product is supplied at 1 mL (100 μL/mL). Due to a high degree of amino acid sequence homology this product is cross-reactive with both CFHR1 and 2.

In humans the complement factor H protein family consists of complement factor H, the factor H-like protein 1 and five factor H-related proteins termed 1 to 5. All members of this group are expressed primarily in the liver and subsequently secreted into plasma. The secreted forms of these proteins are composed exclusively of repetitive protein domains termed short consensus repeats (SCR). The CFHR1 protein is composed of five SCR domains and circulates in plasma as two differentially glycosylated isoforms (37 kDa and 43 kDa). CFHR-2 is composed of four SCRs and is present in human plasma in a non-glycosylated form (24 kDa) and a glycosylated form of 29 kDa. So far the biological functions of both CFHR-1 and CFHR-2 proteins are poorly understood, however recent studies have shown that CFHR1 is a complement regulator that blocks C5 convertase activity as well as assembly and membrane insertion of the terminal components. Moreover, genetic variations in the CFHR1 gene are associated with several diseases such as atypical hemolytic uremic syndrome and age-related macular degeneration.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

CFHR1/CFHR2
Monoclonal
100 μg/mL
PBS with 0.1% BSA and 0.02% sodium azide
P36980, Q03591
CFHR1, CFHR2
Protein G
RUO
3078, 3080
4°C
Liquid
ELISA
JHD-7.10.1
Unconjugated
CFHR2
CFHL; CFHL1; CFHL1P; CFHL2; CFHR1; CFHR1P; CFHR2; complement factor H related 1; complement factor H related 2; complement factor H-related 1 pseudogene; complement factor H-related 2; complement factor H-related protein 1; Complement factor H-related protein 2; DDESK59; factor H-related gene 2; FHR1; FHR-1; FHR2; FHR-2; H factor (complement)-like 1; H factor (complement)-like 2; H factor (complement)-like 3; h factor-like 3; H factor-like protein 1; h factor-like protein 2; H36; H36-1; H36-2; H-factor-like 1; HFL1; HFL2; HFL3
Mouse
100 μg
Primary
Human
Antibody
IgG1
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