Invitrogen™ CFHR5 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA587846

Catalog No. PIPA587846

Description

Immunogen sequence: GPPPSINNGD TTSFPLSVYP PGSTVTYRCQ SFYKLQGSVT VTCRNKQWSE PPRCLDPCVV SEENMNKNNI QLKWRNDGKL YAKTGDAVEF QCKFPHKAMI SSPPFRAICQ EGKFEYPICE; Positive Samples: HepG2, K-562, Mouse liver, Rat liver.

This gene is a member of a small complement factor H (CFH) gene cluster on chromosome 1. Each member of this gene family contains multiple short consensus repeats (SCRs) typical of regulators of complement activation. The protein encoded by this gene has nine SCRs with the first two repeats having heparin binding properties, a region within repeats 5-7 having heparin binding and C reactive protein binding properties, and the C-terminal repeats being similar to a complement component 3 b (C3b) binding domain. This protein co-localizes with C3, binds C3b in a dose-dependent manner, and is recruited to tissues damaged by C-reactive protein. Allelic variations in this gene have been associated, but not causally linked, with two different forms of kidney disease: membranoproliferative glomerulonephritis type II (MPGNII) and hemolytic uraemic syndrome (HUS).

Specifications

• Antigen: CFHR5
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CFHR5
• Gene Alias: CFHL5; CFHR5; CFHR5D; complement factor H related 5; complement factor H-related 5; complement factor H-related protein 5; factor H-related protein 5; FHR5; FHR-5
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 81494
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 3.93 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q9BXR6
• Gene Symbols: CFHR5
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 450-569 of human CFHR5 (NP_1104141).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG