CFLAR Monoclonal Antibody (OTI2H3), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA804485

Catalog No. 50-168-0273

Description

FLIP (CFLAR) is an apoptosis regulator protein which functions as a crucial link between cell survival and cell death pathways in mammalian cells. It acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.

Specifications

• Antigen: CFLAR
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: O15519
• Gene Symbols: CFLAR
• Immunogen: Human recombit protein fragment corresponding to amino acids 1-272 of human CFLAR produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Western Blot
• Clone: OTI2H3
• Conjugate: Unconjugated
• Gene: CFLAR
• Gene Alias: CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLAME1, FLIP, I-FLICE, MRIT, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 8837
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid