CFLAR Mouse anti-Human, Clone: OTI2B9, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF804552

Catalog No. 50-166-7030

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

FLIP (CFLAR) is an apoptosis regulator protein which functions as a crucial link between cell survival and cell death pathways in mammalian cells. It acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.

Specifications

• Antigen: CFLAR
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: CFLAR
• Gene Alias: CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLAME1, FLIP, I-FLICE, MRIT, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 8837
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Western Blot
• Clone: OTI2B9
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: O15519
• Gene Symbols: CFLAR
• Immunogen: Human recombit protein fragment corresponding to amino acids 1-272 of human CFLAR produced in E.coli.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG3