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Tocris Bioscience™ CG 428
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Catalog No. 74255
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Quantity:
5 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Potent tropomyosin receptor kinase (TRK) degrader

CG 428 is a potent tropomyosin receptor kinase (TRK) Degrader (uSMITETM) (DC50 = 0.36 nM). CG 428 comprises an analog of the pan-TRK inhibitor GNF-8625 joined by a linker to the cereblon E3 ligase ligand pomalidomide (Cat. No. 6302). CG 428 shows selectivity for TRKA over TRKC and TRKB (Kd values = 1nM, 4.2 nM and 28 nM, respectively). Inhibits growth of KM12 colon cancer cells (IC50 =2.9 nM) and is bioavailable.

Negative control also available, CG 428-Neg (Cat. No. 7426).

Specifications

Chemical Name or Material 2-(2,6-Dioxo-3-piperidinyl)-4-[[2-[3-[4-[6-[6-[(2 R)-2-(3-fluorophenyl)-1-pyrrolidinyl]imidazo[1,2-b]pyridazin-3-yl]-2-pyridinyl]-1-piperazinyl]-3-oxopropoxy]ethyl]amino]-1 H-isoindole-1,3(2 H)-dione
CAS 2412055-93-5
Quantity 5 mg
Target Active Degraders
Molecular Formula C43H43FN10O6
Purity 0.98
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