Tocris Bioscience™ CG 858

Selective BRAF-V600E protein Degrader (uSMITE™)

Manufacturer:  Tocris Bioscience™ 7427/5

Catalog No. 74-275

Description

CG 858 is a selective BRAF-V600E protein Degrader (uSMITETM). CG 858 comprises the BRAF kinase inhibitor vemurafenib linked to the E3 ligase ligand Thalidomide (Cat. No. 0652). CG 858 dose-dependently degrades BRAF-V600E but not wild type BRAF, and reduces cell viability and colony formation in HT-29 and A375 cells (DC50 values are 124 nM and 500 nM, respectively). Exhibits 88% degradation at 500 nM. CG 858 also impairs melanoma cell growth.

CG 858 negative control (Cat. No. 7428) also available.

Specifications

• Chemical Name or Material: N-[[4-[3-[2,6-Difluoro-3-[(propylsulfonyl)amino]benzoyl]-1 H-pyrrolo[2,3-b]pyridin-5-yl]phenyl]methyl]-5-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1 H-isoindol-5-yl]amino]pentanamide
• Molecular Formula: C₄₂H₃₉F₂N₇O₈S
• CAS: 2417296-82-1

• Purity: 0.98
• Target: Active Degraders
• Quantity: 5 mg

Safety and Handling

Recommended Storage : Store at -20°C