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Invitrogen™ cGKI Polyclonal Antibody
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Catalog No. PIPA582310
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100 μL
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PIPA582310 100 μL
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Catalog No. PIPA582310 Supplier Invitrogen™ Supplier No. PA582310
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: LADVLEETHY ENGEYIIRQG ARGDTFFIIS KGTVNVTRED SPSEDPVFLR TLGKGDWFGE KALQGEDVRT ANVIAAEAVT CLVIDRDSFK HLIGGLDDVS NKAYEDAEAK AKYEAEA Highest antigen sequence indentity to the following orthologs: Mouse - 99%, Rat - 42%.

PRKG1 is a cGMP-dependent serine/threonine kinase which has an important role in the relaxation of vascular smooth muscle and the inhibition of platelet aggregation. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity.
TRUSTED_SUSTAINABILITY

Specifications

Antigen cGKI
Applications Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Concentration 0.10 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene PRKG1
Gene Accession No. Q13976
Gene Alias AAT8; AW125416; cGK; cGK 1; CGK 1 alpha; cGK 1 beta; cGK cGK cGKI; cGK cGK1; cGK1; cGKI; cGKI-alpha; cGKI-BETA; cGMP dependent protein kinase type 1; cGMP kinase type I alpha; cGMP-dependent protein kinase 1; cGMP-dependent protein kinase 1, alpha isozyme; cGMP-dependent protein kinase 1, beta isozyme; cGMP-dependent protein kinase I; Gm19690; OTTHUMP00000019618; PKG; Pkgi; Prkg1; PRKG1B; PRKGR1A; PRKGR1B; protein kinase cGMP-dependent 1; protein kinase, cGMP-dependent, regulatory, type I, beta; protein kinase, cGMP-dependent, type 1; protein kinase, cGMP-dependent, type I; RP11-346D6.1; Unknown (protein for MGC:134126); unnamed protein product
Gene Symbols PRKG1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human PRKG1. Recombinant protein control fragment (Product #RP-89820).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 5592
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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