Invitrogen™ cGKI Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA596164

Catalog No. PIPA596164

Description

Immunogen sequence: MGTLRDLQYA LQEKIEELRQ RDALIDELEL ELDQKDELIQ KLQNELDKYR SVIRPATQQA QKQSASTLQG EPRTKRQAIS AEPTAFDIQD LSHVTLPFYP KSPQSKDLIK EAILDNDFMK NLELSQIQEI VDCMYPVEYG KDSCIIKEGD VGSLVYVMED GKVEVTKEGV KLCTMGPGKV FGELAILYNC TRTATVKTLV NVKLWAIDRQ CFQTIMMRTG LIKHTEYMEF LKSVPTFQSL PEEILSKLAD VLEETHYENG EYIIRQGARG DTFFIISKGT VNVTREDSPS EDPVFLRTLG; Positive Samples: HepG2; Cellular Location: Cytoplasm.

PRKG1 is a cGMP-dependent serine/threonine kinase which has an important role in the relaxation of vascular smooth muscle and the inhibition of platelet aggregation. The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, and modulating cell growth. This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Ialpha and Ibeta have identical cGMP-binding and catalytic domains but differ in their leucine/isoleucine zipper and autoinhibitory sequences and therefore differ in their dimerization substrates and kinase enzyme activity.

Specifications

• Antigen: cGKI
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PRKG1
• Gene Alias: AAT8; AW125416; cGK; cGK 1; CGK 1 alpha; cGK 1 beta; cGK cGK cGKI; cGK cGK1; cGK1; cGKI; cGKI-alpha; cGKI-BETA; cGMP dependent protein kinase type 1; cGMP kinase type I alpha; cGMP-dependent protein kinase 1; cGMP-dependent protein kinase 1, alpha isozyme; cGMP-dependent protein kinase 1, beta isozyme; cGMP-dependent protein kinase I; Gm19690; OTTHUMP00000019618; PKG; Pkgi; Prkg1; PRKG1B; PRKGR1A; PRKGR1B; protein kinase cGMP-dependent 1; protein kinase, cGMP-dependent, regulatory, type I, beta; protein kinase, cGMP-dependent, type 1; protein kinase, cGMP-dependent, type I; RP11-346D6.1; Unknown (protein for MGC:134126); unnamed protein product
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 19091, 5592
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 1.85 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P0C605, Q13976
• Gene Symbols: PRKG1
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human PRKG1 (NP_0062491).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG