Invitrogen™ cGKII Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA552426

Catalog No. PIPA552426

Description

Immunogen sequence: REYHLKELRE QLSKQTVAIA ELTEELQNKC IQLNKLQDVV HMQGGSPLQA SPDKVPLEVH RKTSGLVSLH SRRGAKAGVS AEPTTRTYDL NKPPEFSFEK ARVRKDSSEK KLITDALNKN QFLKRLDPQQ IKDMVE Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 96%.

PRKG2 (PKG2, cGKII) exhibits many cellular functions and has cAMP- and cGMP-dependent protein kinase activity. cGKII is thought to play a key role in a diverse set of physiological pathway. cGKII may mediate intestinal secretion of water and electrolytes induced by the E. coli toxin STa and the intestinal peptide guanylin. Identification of the pathway that mediates intestinal fluid secretion by E. coli. cGKII is postulated to be a molecular switch that couples the cessation of proliferation and the start of hypertrophic chondrocyte differentiation through attenuating SOX9 function.

Specifications

• Antigen: cGKII
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: PRKG2
• Gene Alias: AW212535; cGK 2; cGK2; cGKII; cGK-II; cGMP dependent protein kinase type II; cGMP-dependent protein kinase 2; cGMP-dependent protein kinase II; EC 2.7.11.12; GDPKII; PRKG2; PRKGR2; protein kinase cGMP- dependent type 2; protein kinase, cGMP- dependent, type 2; protein kinase, cGMP- dependent, type II; protein kinase, cGMP-dependent, type II; testicular tissue protein Li 99; type II cGMP-dependent protein kinase
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 5593
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q13237
• Gene Symbols: PRKG2
• Immunogen: Recombinant protein corresponding to Human cGKII. Recombinant protein control fragment (Product #RP-102027).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG