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Invitrogen™ CH25H Polyclonal Antibody
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Catalog No. PIPA572349
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200 μL
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PIPA572349 200 μL
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Catalog No. PIPA572349 Supplier Invitrogen™ Supplier No. PA572349
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Description

Rabbit Polyclonal Antibody

CH25H Polyclonal Antibody for Western Blot

Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes (PubMed:9852097). Plays a key role in cell positioning and movement in lymphoid tissues: 25-hydroxycholesterol is an intermediate in biosynthesis of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC), an oxysterol that acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing. In testis, production of 25-hydroxycholesterol by macrophages may play a role in Leydig cell differentiation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CH25H
Applications Western Blot
Classification Polyclonal
Concentration 2 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide; pH 7.4
Gene CH25H
Gene Accession No. O95992, Q9Z0F5
Gene Alias 1.14.99.38; AI462618; C25H; CH25H; ch25hb; cholesterol 25-hydroxylase; Cholesterol 25-hydroxylase-like protein; cholesterol 25-monooxygenase; h25OH; m25OH; Unknown (protein for MGC:143045); zgc:101688
Gene Symbols CH25H
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide between 47-76 amino acids from human CH25H.
Purification Method Protein A, Antigen affinity chromatography
Quantity 200 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12642, 9023
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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