Invitrogen™ CH25H Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA570691

Catalog No. PIPA570691

Description

This target displays homology in the following species: Cow: 93%; Goat: 83%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 93%; Rabbit: 93%; Rat: 93%; Yeast: 75%; Zebrafish: 86%.

Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes (PubMed:9852097). Plays a key role in cell positioning and movement in lymphoid tissues: 25-hydroxycholesterol is an intermediate in biosynthesis of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC), an oxysterol that acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing. In testis, production of 25-hydroxycholesterol by macrophages may play a role in Leydig cell differentiation.

Specifications

• Antigen: CH25H
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CH25H
• Gene Alias: 1.14.99.38; AI462618; C25H; CH25H; ch25hb; cholesterol 25-hydroxylase; Cholesterol 25-hydroxylase-like protein; cholesterol 25-monooxygenase; h25OH; m25OH; Unknown (protein for MGC:143045); zgc:101688
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 9023
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot, Surface Plasmon Resonance
• Concentration: 0.5 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene Accession No.: O95992
• Gene Symbols: CH25H
• Immunogen: synthetic peptide directed towards the C-terminal region of human CH25H.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG