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Invitrogen™ CH25H Polyclonal Antibody
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Catalog No. PIPA570691
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100 μL
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PIPA570691 100 μL
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Catalog No. PIPA570691 Supplier Invitrogen™ Supplier No. PA570691
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Description

Rabbit Polyclonal Antibody

This target displays homology in the following species: Cow: 93%; Goat: 83%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 93%; Rabbit: 93%; Rat: 93%; Yeast: 75%; Zebrafish: 86%.

Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes (PubMed:9852097). Plays a key role in cell positioning and movement in lymphoid tissues: 25-hydroxycholesterol is an intermediate in biosynthesis of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC), an oxysterol that acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing. In testis, production of 25-hydroxycholesterol by macrophages may play a role in Leydig cell differentiation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CH25H
Applications Western Blot, Surface Plasmon Resonance
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 2% sucrose and 0.09% sodium azide
Gene CH25H
Gene Accession No. O95992
Gene Alias 1.14.99.38; AI462618; C25H; CH25H; ch25hb; cholesterol 25-hydroxylase; Cholesterol 25-hydroxylase-like protein; cholesterol 25-monooxygenase; h25OH; m25OH; Unknown (protein for MGC:143045); zgc:101688
Gene Symbols CH25H
Host Species Rabbit
Immunogen synthetic peptide directed towards the C-terminal region of human CH25H.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9023
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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