Invitrogen™ CHCHD6 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA588859

Catalog No. PIPA588859

Description

Immunogen sequence: MGSTESSEGR RVSFGVDEEE RVRVLQGVRL SENVVNRMKE PSSPPPAPTS STFGLQDGNL RAPHKESTLP RSGSSGGQQP SGMKEGVKRY EQEHAAIQDK LFQVAKRERE AATKHSKASL PTGEGSISHE EQKSVRLARE LESREAELRR RDTFYKEQLE RIERKNAEMY KLSSEQFHEA ASKMESTIKP RRVEPVCSGL QAQILHCYRD RPHEVLLCSD LVKAYQRCVS AAHKG; Positive Samples: A-549, HeLa; Cellular Location: Lipid-anchor, Mitochondrion, Mitochondrion inner membrane.

CHCHD6 is a member of a family of proteins containing a conserved (coiled coil 1)-(helix 1)-(coiled coil 2)-(helix 2) domain and has been observed in a complex with the mitochondrial proteins mitofilin, SAM50, metaxins 1 and 2, and CHCHD3. CHCHD6 knockdown causes severe defects in mitochondrial cristae morphology as well as reductions in cell growth, ATP production and oxygen consumption. This decrease of CHCHD6 also led to a reduction in mitofilin protein levels, while a knockdown of mitofilin resulted in a reduced level of CHCHD6, suggesting coordinate regulation between these two proteins. CHCHD6 knockdown in human cancer cells enhances their sensitivity to genotoxic anticancer drugs, suggesting that CHCHD6 may be a potential therapeutic anti-tumor target.

Specifications

• Antigen: CHCHD6
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CHCHD6
• Gene Alias: 0710001P09Rik; 1700021B03Rik; CHCHD6; CHCM1; coiled coil helix cristae morphology 1; coiled coil helix cristae morphology protein 1; coiled-coil-helix cristae morphology 1; coiled-coil-helix cristae morphology protein 1; coiled-coil-helix-coiled-coil-helix domain containing 6; Coiled-coil-helix-coiled-coil-helix domain-containing protein 6; coiled-coil-helix-coiled-coil-helix domain-containing protein 6, mitochondrial; Mic25; MICOS complex subunit MIC25; PPP1R23; protein phosphatase 1, regulatory subunit 23
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 84303
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 3.26 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: Q9BRQ6
• Gene Symbols: CHCHD6
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-235 of human CHCHD6 (NP_1157191).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG