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CHCHD6 Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501988331
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50-198-8331 100 μL
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Catalog No. 50-198-8331 Supplier Bioss Supplier No. BS8167R
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Description

Rabbit Polyclonal Antibody

CHCHD6 is a member of a family of proteins containing a conserved (coiled coil 1)-(helix 1)-(coiled coil 2)-(helix 2) domain and has been observed in a complex with the mitochondrial proteins mitofilin, SAM50, metaxins 1 and 2, and CHCHD3. CHCHD6 knockdown causes severe defects in mitochondrial cristae morphology as well as reductions in cell growth, ATP production and oxygen consumption. This decrease of CHCHD6 also led to a reduction in mitofilin protein levels, while a knockdown of mitofilin resulted in a reduced level of CHCHD6, suggesting coordinate regulation between these two proteins. CHCHD6 knockdown in human cancer cells enhances their sensitivity to genotoxic anticancer drugs, suggesting that CHCHD6 may be a potential therapeutic anti-tumor target.

Specifications

Antigen CHCHD6
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene CHCHD6
Gene Accession No. Q9BRQ6
Gene Alias Chchd6; CHCM1; coiled coil helix cristae morphology 1; coiled coil helix cristae morphology protein 1; coiled-coil-helix cristae morphology 1; Coiled-coil-helix cristae morphology protein 1; coiled-coil-helix-coiled-coil-helix domain containing 6; Coiled-coil-helix-coiled-coil-helix domain-containing protein 6; coiled-coil-helix-coiled-coil-helix domain-containing protein 6, mitochondrial; Mic25; MICOS complex subunit Mic25; PPP1R23; protein phosphatase 1, regulatory subunit 23
Gene Symbols CHCHD6
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human CHCHD6.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 84303
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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