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Chd5 Monoclonal Antibody (5A10), Active Motif™
SDP

Catalog No. 501993616
Encompass
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50-199-3616 100 μg
50-199-3617 10 μg
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Catalog No. 50-199-3616 Supplier Active Motif Supplier No. 61683
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Description

Rat Monoclonal Antibody

CHD5 (Chromodomain helicase DNA binding protein 5) is a member of the SNF2/RAD54 helicase family of chromatin remodeling and DNA-binding proteins (CDH proteins). Heavily expressed in both fetal and adult brain, CHD5 plays a role in nervous system development and acts as a tumor suppressor via the Arf/p53 pathway. CHD5, along with other chromo-domain proteins, forms remodeling complexes, such as NuRD, that promote normal neuroblast maturation and are thought to prevent overexpression of neuronal cells. Errors in these chromatin remodeling complexes can leave the cell in a perpetual state of growth, preventing differentiation and leading to tumor formation. Due to the importance of the CHD proteins in proper brain development, deletions in the gene encoding CHD5 are commonly found in neuroblastomas, suggesting that CHD5 deficiency may lead to malignant cell transformation and metastasis.

Specifications

Antigen Chd5
Applications Immunocytochemistry, Immunofluorescence, Western Blot
Classification Monoclonal
Clone 5A10
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 30% glycerol and 0.035% sodium azide; pH 7.5
Gene CHD5
Gene Accession No. A2A8L1, Q8TDI0
Gene Alias 4930532L22Rik; ATP-dependent helicase CHD5; AW060752; B230399N07Rik; CHD5; CHD-5; chromodomain helicase DNA binding protein 5; Chromodomain-helicase-DNA-binding protein 5; KIAA0444
Gene Symbols CHD5
Host Species Rat
Immunogen This antibody was raised against a peptide within the C-terminal region of mouse Chd5.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 26038, 269610
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG2a
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