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Invitrogen™ CHD5 Polyclonal Antibody
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Catalog No. PIPA563133
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100 μL
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PIPA563133 100 μL
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Catalog No. PIPA563133 Supplier Invitrogen™ Supplier No. PA563133
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: GYMDEKDPGA QKPRQPLEVQ ALPAALDRVE SEDKHESPAS KERAREERPE ETEKAPPSPE QLPREEVLPE KEKILDKLEL SLIHSR Highest antigen sequence identity to the following orthologs: Mouse - 67%, Rat - 67%.

CHD5 (Chromodomain helicase DNA binding protein 5) is a member of the SNF2/RAD54 helicase family of chromatin remodeling and DNA-binding proteins (CDH proteins). Heavily expressed in both fetal and adult brain, CHD5 plays a role in nervous system development and acts as a tumor suppressor via the Arf/p53 pathway. CHD5, along with other chromo-domain proteins, forms remodeling complexes, such as NuRD, that promote normal neuroblast maturation and are thought to prevent overexpression of neuronal cells. Errors in these chromatin remodeling complexes can leave the cell in a perpetual state of growth, preventing differentiation and leading to tumor formation. Due to the importance of the CHD proteins in proper brain development, deletions in the gene encoding CHD5 are commonly found in neuroblastomas, suggesting that CHD5 deficiency may lead to malignant cell transformation and metastasis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CHD5
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene CHD5
Gene Accession No. Q8TDI0
Gene Alias 4930532L22Rik; ATP-dependent helicase CHD5; AW060752; B230399N07Rik; CHD5; CHD-5; chromodomain helicase DNA binding protein 5; chromodomain-helicase-DNA-binding protein 5; KIAA0444
Gene Symbols CHD5
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human CHD5. Recombinant protein control fragment (Product #RP-103713).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 26038
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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