Invitrogen™ CHD7 Polyclonal Antibody

Goat Polyclonal Antibody

Supplier:  Invitrogen™ PA5142285

Catalog No. PIPA5142285

Description

This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:64,000.

Chromodomain helicase DNA binding protein 7 (CHD7) is a gene located on chromosome 8q12.2 that encodes a member of the chromodomain helicase DNA-binding (CHD) family, which plays a pivotal role in chromatin remodeling and gene expression regulation. CHD7 contains multiple domains that facilitate its involvement in modifying chromatin structure, thereby influencing the accessibility of DNA for transcription factors and other regulatory proteins. The protein is integral to various developmental processes, including neural crest formation, thus affecting tissues such as the nervous system, skeletal structures, and sensory organs. Mutations in CHD7 are associated with CHARGE syndrome, a multisystem disorder characterized by congenital anomalies including coloboma, heart defects, and ear abnormalities. CHD7's role in chromatin dynamics makes it crucial for normal embryonic development and cellular differentiation. Ongoing research is focused on uncovering CHD7's broader implications in developmental biology and its potential as a therapeutic target in chromatin-related disorders.

Specifications

• Antigen: CHD7
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CHD7
• Gene Alias: A730019I05Rik; ATP-dependent helicase CHD7; CHARGE association; CHD7; CHD-7; chromodomain helicase DNA binding protein 7; chromodomain helicase DNA binding protein 7 isoform CRA_e; chromodomain-helicase-DNA-binding protein 7; CRG; Cycn; Cyn; Dz; Edy; Flo; GENA 47; Gena 52; GENA 60; HH5; IS3; KAL5; KIAA1416; Lda; metis; Mt; Obt; Todo; WBE1; Whi
• Host Species: Goat
• Purification Method: Ammonium Sulfate Precipitation
• Regulatory Status: RUO
• Gene ID (Entrez): 55636
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.5 mg/mL
• Formulation: TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q9P2D1
• Gene Symbols: CHD7
• Immunogen: Peptide with sequence C-KDEIDEFANSPSE.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG