Invitrogen™ CHD7 Polyclonal Antibody

Sheep Polyclonal Antibody

Supplier:  Invitrogen™ PA547918

Catalog No. PIPA547918

Description

Reconstitute in sterile PBS to a final concentration of 0.2 mg/mL.

Chromodomain helicase DNA binding protein 7 (CHD7) is a gene located on chromosome 8q12.2 that encodes a member of the chromodomain helicase DNA-binding (CHD) family, which plays a pivotal role in chromatin remodeling and gene expression regulation. CHD7 contains multiple domains that facilitate its involvement in modifying chromatin structure, thereby influencing the accessibility of DNA for transcription factors and other regulatory proteins. The protein is integral to various developmental processes, including neural crest formation, thus affecting tissues such as the nervous system, skeletal structures, and sensory organs. Mutations in CHD7 are associated with CHARGE syndrome, a multisystem disorder characterized by congenital anomalies including coloboma, heart defects, and ear abnormalities. CHD7's role in chromatin dynamics makes it crucial for normal embryonic development and cellular differentiation. Ongoing research is focused on uncovering CHD7's broader implications in developmental biology and its potential as a therapeutic target in chromatin-related disorders.

Specifications

• Antigen: CHD7
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CHD7
• Gene Alias: A730019I05Rik; ATP-dependent helicase CHD7; CHARGE association; CHD7; CHD-7; chromodomain helicase DNA binding protein 7; chromodomain helicase DNA binding protein 7 isoform CRA_e; chromodomain-helicase-DNA-binding protein 7; CRG; Cycn; Cyn; Dz; Edy; Flo; GENA 47; Gena 52; GENA 60; HH5; IS3; KAL5; KIAA1416; Lda; metis; Mt; Obt; Todo; WBE1; Whi
• Host Species: Sheep
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 55636
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Western Blot, Immunocytochemistry
• Concentration: 0.2 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: Q9P2D1
• Gene Symbols: CHD7
• Immunogen: E. coli-derived recombinant human CHD7 Ala263-Gln457.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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