Invitrogen™ CHD7 Polyclonal Antibody

Catalog No.	Quantity
PIPA565762	100 μL

Catalog No. PIPA565762 Supplier Invitrogen™ Supplier No. PA565762

Description

Rabbit Polyclonal Antibody

Immunogen sequence: ALNLSVPRQRR RRRRKIEIEA ERAAKRRNLM EMVAQLRESQ VVSENGQEKV VDLSKASREA TSSTSNFSSL SSKFILPNVS TPVSDAFKTQ MEL Highest antigen sequence identity to the following orthologs - mouse 97%, rat 98%.

Chromodomain helicase DNA binding protein 7 (CHD7) is a gene located on chromosome 8q12.2 that encodes a member of the chromodomain helicase DNA-binding (CHD) family, which plays a pivotal role in chromatin remodeling and gene expression regulation. CHD7 contains multiple domains that facilitate its involvement in modifying chromatin structure, thereby influencing the accessibility of DNA for transcription factors and other regulatory proteins. The protein is integral to various developmental processes, including neural crest formation, thus affecting tissues such as the nervous system, skeletal structures, and sensory organs. Mutations in CHD7 are associated with CHARGE syndrome, a multisystem disorder characterized by congenital anomalies including coloboma, heart defects, and ear abnormalities. CHD7's role in chromatin dynamics makes it crucial for normal embryonic development and cellular differentiation. Ongoing research is focused on uncovering CHD7's broader implications in developmental biology and its potential as a therapeutic target in chromatin-related disorders.

Specifications

• Antigen: CHD7
• Applications: ChIP Assay, Immunocytochemistry
• Classification: Polyclonal
• Concentration: 0.2 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene: CHD7
• Gene Accession No.: Q9P2D1
• Gene Alias: A730019I05Rik; ATP-dependent helicase CHD7; CHARGE association; CHD7; CHD-7; chromodomain helicase DNA binding protein 7; chromodomain helicase DNA binding protein 7 isoform CRA_e; chromodomain-helicase-DNA-binding protein 7; CRG; Cycn; Cyn; Dz; Edy; Flo; GENA 47; Gena 52; GENA 60; HH5; IS3; KAL5; KIAA1416; Lda; metis; Mt; Obt; Todo; WBE1; Whi
• Gene Symbols: CHD7
• Host Species: Rabbit
• Immunogen: Recombinant Human CHD7. Recombinant protein control fragment (Product #RP-103634).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 55636
• Target Species: Human
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG