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Tocris Bioscience™ CHDI 00580985

Catalog No. 788110
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78-811-0 10 mg
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Catalog No. 78-811-0 Supplier Tocris Bioscience™ Supplier No. 7881/10
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Description

Potent and selective ROCK inhibitor; orally bioavailable and brain penetrant

CHDI 00580985 is a potent and selective ROCK inhibitor (IC50 values are 3 nM and 8 nM in biochemical (ROCK2) and cellular assays respectively). CHDI 00580985 inhibits ROCK-mediated substrate (MYPT1) phosphorylation (IC50 = 4 nM). In vivo, CHDI 00580985 reduces ROCK signaling in Huntington's disease mouse models in pharmacodynamic assay. CHDI 00580985 is bioavailable and brain penetrant.

Specifications

Chemical Name or Material (2R)-4-(3-Fluoro-4-pyridinyl)-N-[(1R)-1-(3-methoxyphenyl)ethyl]-2-methyl-1-piperazinecarboxamide
CAS 2573071-18-6
Quantity 10 mg
Target Rho-kinase Inhibitors
Molecular Formula C20H25FN4O2
Purity 0.98
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