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Tocris Bioscience™ CHDI 113
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Catalog No. 80635
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80-635 5 mg
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Catalog No. 80-635 Supplier Tocris Bioscience™ Supplier No. 8063/5
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Description

Potent HTT pre-RNA splicing modulator

CHDI 113 is a potent huntingtin (HTT) pre-mRNA splicing modulator (EC50 = 66 nM). It lowers HTT protein in both human Huntington's disease (HD) stem cells and in the brain of BACHD (bacterial artificial chromosome-mediated transgenic) mouse model. CHDI 113 is brain penetrant and orally bioavailable.

Specifications

Chemical Name or Material 5-[(3R)-3-(Cyclopropylamino)-1-pyrrolidinyl]-N-(8-fluoro-2-methylimidazo[1,2-a]pyridin-6-yl)-2-pyrazinecarboxamide
CAS 2743336-70-9
Quantity 5 mg
Target Huntingtin
Molecular Formula C20H22FN7O
Purity 0.98
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