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CHEK2 Mouse anti-Canine, Human, Clone: OTI4C10, liquid, TrueMAB™
SDP

Mouse Monoclonal Antibody

Supplier:  OriGene TA500385

Encompass_Preferred

Catalog No. 50-167-1519


May include imposed supplier surcharges.
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Description

Description

Checkpoint kinase 2 (Chk2) is a serine/threonine-protein kinase which functions as a cell cycle checkpoint regulator. ATM and ATR kinases are activated in response to ionizing and ultraviolet radition, and phosphorylate Thr68 and other sites in the amino-terminal region of Chk2 dimerisation and activation. Activated Chk2 phosphorylates and inhibits Cdc25C phosphates, preventing the entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, Chk2 can phosphorylate BRCA1, allowing BRCA1 to restore survival after DNA damage. Chk2 is a putative tumor suppressor protein, with mutations in to the Chk2 gene linked to Li-Fraumeni syndrome, a familiar cancer usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors.
Specifications

Specifications

CHEK2
Monoclonal
1.88 mg/mL
PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
O96017
CHEK2
Full length human recombit protein of human CHEK2 produced in HEK293T cell.
100 μL
Primary
Canine, Human
Antibody
IgG2b
Flow Cytometry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
OTI4C10
Unconjugated
CHEK2
CDS1, CHK2, HuCds1, LFS2, PP1425, RAD53, hCds1
Mouse
Affinity Chromatography
RUO
11200, 486338
-20° C, Avoid Freeze/Thaw Cycles
Liquid
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