CHEK2 Mouse anti-Canine, Human, Clone: OTI4C10, liquid, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene TA500385

Catalog No. 50-167-1519

Description

Checkpoint kinase 2 (Chk2) is a serine/threonine-protein kinase which functions as a cell cycle checkpoint regulator. ATM and ATR kinases are activated in response to ionizing and ultraviolet radition, and phosphorylate Thr68 and other sites in the amino-terminal region of Chk2 dimerisation and activation. Activated Chk2 phosphorylates and inhibits Cdc25C phosphates, preventing the entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, Chk2 can phosphorylate BRCA1, allowing BRCA1 to restore survival after DNA damage. Chk2 is a putative tumor suppressor protein, with mutations in to the Chk2 gene linked to Li-Fraumeni syndrome, a familiar cancer usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors.

Specifications

• Antigen: CHEK2
• Classification: Monoclonal
• Concentration: 1.88 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: O96017
• Gene Symbols: CHEK2
• Immunogen: Full length human recombit protein of human CHEK2 produced in HEK293T cell.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Canine, Human
• Product Type: Antibody
• Isotype: IgG2b

• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Clone: OTI4C10
• Conjugate: Unconjugated
• Gene: CHEK2
• Gene Alias: CDS1, CHK2, HuCds1, LFS2, PP1425, RAD53, hCds1
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 11200, 486338
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid