CHFR Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-172-7765	Proteintech Group Inc 121691AP150UL	150 μL

Description

E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the ′Lys-48′-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURKA and PLK1. Probably acts as a tumor suppressor, possibly by mediating the polyubiquitination of HDAC1, leading to its degradation. May also promote the formation of ′Lys-63′-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer. Substrates that are polyubiquitinated at ′Lys-63′ are usually not targeted for degradation, but are rather involved in signaling cellular stress.

Specifications

• Antigen: CHFR
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse, Rat
• Gene Accession No.: Q810L3, Q96EP1
• Gene ID (Entrez): 231600, 288734, 55743
• Immunogen: CHFR Fusion Protein Ag2811
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: CHFR

• Concentration: 0.27 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Alias: CHFR, RING finger protein 196, RNF116, RNF196
• Gene Symbols: Chfr
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody