MilliporeSigma Chicken anti-IGF-IRα subunit, Polyclonal,
Chicken Polyclonal Antibody
Manufacturer: MilliporeSigma 06429I
Specifically detects IGF-IRα subunit in Human samples, and it is validated for Immunocytochemistry, Immunoprecipitation, Western BlottingInsulin-like growth factor 1 receptor (EC:220.127.116.11; UniProt P08069; also known as CD221, IGF-I receptor, Insulin-like growth factor I receptor) is encoded by the IGF1R (also known as CD221, IGFIR, IGFR, JTK13) gene (Gene ID 3480) in human. The insulin-like growth factor 1 (IGF-1) receptor has tyrosine kinase that is activated by IGF-1 and IGF-2 binding. IGF-1 receptor is initially produced as a precursor protein with an aignal peptide sequence (aa 1-30). Post-translational cleavages produce one extracellular alpha (aa 31-736) chain and one transmembrane beta chain (aa 741 – 1367) linked together by a disulfide bond. Two sets of alpha-beta dimers then form the functional tetrameric receptor complex via a disulfide linkage between their alpha chain. Upon ligand binding, the alpha chains induce the tyrosine auto-phosphorylation of the beta chains, which in turn triggers cell type-specific downstream signaling cascade of events.
|Purified chicken polyclonal IgY antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.|
|Immunocytochemistry, Immunoprecipitation, Western Blot|
|KLH-conjugated synthetic peptide [C-KYADGTIDIEEVTENPKT] corresponding to amino acid residues 672-689 of human IGF-IR alpha chain.|
|Stable for one year at 2°C to 8°C from date of receipt.|
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