TP53, Chicken, Biotin, Polyclonal Antibody, Abnova™

Chicken polyclonal antibody against synthetic phosphopeptide of TP53

Supplier:  Abnova Corporation PAB27985

Catalog No. 89-129-500

Description

This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of this gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome. Multiple p53 variants due to alternative promoters and multiple alternative splicing have been found. These variants encode distinct isoforms, which can regulate p53 transcriptional activity. [provided by RefSeq

Sequence: MEEPQSDPSVEPPL(pS)QETFSDLWK

Specifications

• Antigen: TP53
• Classification: Polyclonal
• Conjugate: Biotin
• Formulation: In Phosphate-Buffered Saline with 0.02% Sodium Azide.
• Gene Alias: FLJ92943/LFS1/TRP53/p53
• Host Species: Chicken
• Purification Method: Antigen affinity purification
• Regulatory Status: RUO
• Gene ID (Entrez): 7157
• Content And Storage: Store at 4°C. For long term storage aliquot and store at -20°C. Avoid repeated freezing and thawing cycles.
• Isotype: IgY

• Applications: Immuno-MRM (multiple reaction monitoring)
• Concentration: 0.2 mg/mL
• Description: Chicken polyclonal antibody against synthetic phosphopeptide of TP53
• Gene: TP53
• Gene Symbols: TP53
• Immunogen: Synthetic phosphopeptide corresponding to amino acids of TP53
• Quantity: 20 μg
• Primary or Secondary: Primary
• Target Species: Human
• Form: Liquid

For Research Use Only