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Invitrogen™ CHIL3 Monoclonal Antibody (281926)
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Catalog No. PIMA523981
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100 μg
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Catalog No. Quantity
PIMA523981 100 μg
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Catalog No. PIMA523981 Supplier Invitrogen™ Supplier No. MA523981
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Description

Rat Monoclonal Antibody

Reconstitute at 0.5 mg/mL in sterile PBS.

The CHIL3 gene encodes the protein chitinase-like 3, which is primarily secreted by macrophages and is involved in immune regulation, tissue remodeling, and inflammatory responses. CHIL3, also known as Ym1, belongs to the chitinase-like protein family but lacks chitinase activity due to mutations in its catalytic domain. It is predominantly expressed in lung tissue, where it plays a vital role in asthmatic responses and allergic inflammation. Furthermore, CHIL3 exerts anti-inflammatory roles during pathogen infection by modulating macrophage pro-inflammatory activity and promoting the Th2 immune response. Beyond immunological involvement, CHIL3 is integral to tissue repair mechanisms and cancer cell proliferation, contributing to extracellular matrix restructuring and angiogenesis. It facilitates macrophage polarization towards an M2 phenotype, which is associated with tumor progression and metastasis. Thus, CHIL3 is considered a potential biomarker for inflammatory diseases and cancer, with ongoing research examining its therapeutic modulation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CHIL3
Applications Western Blot
Classification Monoclonal
Clone 281926
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene Chil3
Gene Accession No. O35744
Gene Alias AI505981; beta-N-acetylhexosaminidase Ym1; Chi3l3; Chil3; chitinase 3-like 3; chitinase-3-like protein 3; chitinase-like 3; chitinase-like protein 3; ECF-L; eosinophil chemotactic cytokine; eosinophil chemotactic factor-L; secreted protein Ym1; Ym1
Gene Symbols Chil3
Host Species Rat
Immunogen Mouse myeloma cell line NS0-derived recombinant mouse Chitinase 3-like 3/ECF-L Tyr22-Tyr398.
Purification Method Protein A/G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12655
Target Species Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG2a
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