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Invitrogen™ CHIL3 Polyclonal Antibody
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Catalog No. PIPA581356
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100 μL
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PIPA581356 100 μL
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Catalog No. PIPA581356 Supplier Invitrogen™ Supplier No. PA581356
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Description

Rabbit Polyclonal Antibody

This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%). This antibody has specificity for Mouse Chitinase-like 3/Chi3l3.

The CHIL3 gene encodes the protein chitinase-like 3, which is primarily secreted by macrophages and is involved in immune regulation, tissue remodeling, and inflammatory responses. CHIL3, also known as Ym1, belongs to the chitinase-like protein family but lacks chitinase activity due to mutations in its catalytic domain. It is predominantly expressed in lung tissue, where it plays a vital role in asthmatic responses and allergic inflammation. Furthermore, CHIL3 exerts anti-inflammatory roles during pathogen infection by modulating macrophage pro-inflammatory activity and promoting the Th2 immune response. Beyond immunological involvement, CHIL3 is integral to tissue repair mechanisms and cancer cell proliferation, contributing to extracellular matrix restructuring and angiogenesis. It facilitates macrophage polarization towards an M2 phenotype, which is associated with tumor progression and metastasis. Thus, CHIL3 is considered a potential biomarker for inflammatory diseases and cancer, with ongoing research examining its therapeutic modulation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CHIL3
Applications ELISA, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative
Gene Chil3
Gene Accession No. O35744
Gene Alias AI505981; beta-N-acetylhexosaminidase Ym1; Chi3l3; Chil3; chitinase 3-like 3; chitinase-3-like protein 3; chitinase-like 3; chitinase-like protein 3; ECF-L; eosinophil chemotactic cytokine; eosinophil chemotactic factor-L; secreted protein Ym1; Ym1
Gene Symbols Chil3
Host Species Rabbit
Immunogen Recombinant Mouse Chitinase-like 3/Chi3l3 Protein (Met1-Tyr398).
Purification Method Antigen affinity chromatography, Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12655
Target Species Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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