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  5. Tocris Bioscience™ CHIR 98014

Tocris Bioscience™ CHIR 98014
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Catalog No. 66955
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Catalog No. Quantity
66-955 5 mg
66-952-5 25 mg
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Catalog No. 66-955 Supplier Tocris Bioscience™ Supplier No. 6695/5
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Description

Highly potent and selective GSK-3 inhibitor

CHIR 98014 is a highly potent and selective GSK-3 inhibitor (IC50 values are 0.58 and 0.65 nM for the β and α isoforms, respectively). Exhibits >500-fold selectivity for GSK-3β over a range of other kinases. Improves insulin sensitivity of muscle strips from diabetic rats in vitro and decreases insulin and glucose levels in the oral glucose tolerance test in vivo. Activates Wnt signaling in human adipose stem cells (hASC) and promotes the production of definitive endoderm. Has been used in protocols to derive epicardial cells from hPSCs.

Specifications

Quantity 5 mg
Molecular Formula C20H17Cl2N9O2
Formula Weight 486.31
Product Type Inhibitor
Purity 98%
Product Title
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