Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. Protein Analysis Reagents
  4. Bioactive Small Molecules
  5. 81706

Tocris Bioscience™ CHIR 99021 in solution

Catalog No. 81706
Change view
Click to view available options
Quantity:
6 mg
1 product options available for selection
Product selection table with 1 available options. Use arrow keys to navigate and Enter or Space to select.
Catalog No. Quantity
81-706 6 mg
Use arrow keys to navigate between rows. Press Enter or Space to select a product option. 1 options available.
1 options
This item is not returnable. View return policy
Catalog No. 81-706 Supplier Tocris Bioscience™ Supplier No. 8170/6
Only null left
Add to Cart
Add to Cart
This item is not returnable. View return policy

Description

Sterile-filtered 10 mM solution of CHIR 99021 pre-dissolved in DMSO

CHIR 99021 in solution is a convenient and ready-to-use 10 mM sterile-filtered solution of CHIR 99021 (Cat. No. 4423) pre-dissolved in DMSO. A potent and highly selective inhibitor of glycogen synthase kinase 3 (GSK-3) (IC50 values are 6.7 and 10 nM for GSK-3β and GSK-3α respectively). Acts as Wnt activator. In combination with the irreversible inhibitor of LSD1, Tranylcypromine (Cat. No. 3852), CHIR 99021 enables reprogramming of mouse embryonic fibroblasts into iPSCs. Enhances mouse and human ESC self-renewal when used in combination with PD 0325901 (Cat. No. 4192); promotes differentiation of hPSCs in cardiomyocytes and allows formation of extended pluripotent stem (EPS) cells in combination with (S)-(+)-Dimethindene maleate (Cat. No. 1425), Minocycline (Cat. No. 3268) and human leukemia inhibitory factor.

CHIR 99021 synthesized to cGMP guidelines also available.

Specifications

Chemical Name or Material 6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile
CAS 252917-06-9
Quantity 6 mg
Target GSK-3 Inhibitors
Molecular Formula C22H18Cl2N8
Purity 0.97
Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.