Invitrogen™ Chitotriosidase Monoclonal Antibody (397504)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA524132

Catalog No. PIMA524132

Description

In direct ELISAs, no cross-reactivity with recombinant human CHI3L1 is observed. Reconstitute at 0.5 mg/mL in sterile PBS.

Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens.

Specifications

• Antigen: Chitotriosidase
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: Q13231
• Gene Symbols: CHIT1
• Immunogen: Mouse myeloma cell line NS0-derived recombinant human Chitotriosidase/CHIT1 Ala22-Asn466.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunoprecipitation, Neutralization
• Clone: 397504
• Conjugate: Unconjugated
• Gene: CHIT1
• Gene Alias: 2300002L19Rik; CHI3; CHIT; Chit1; CHITD; chitinase 1; chitinase 1 (chitotriosidase); chitinase-1; Chitotriosidase; Chitotriosidase-1; EC 3.2.1.14; FLJ00314; MGC125322; plasma methylumbelliferyl tetra-N-acetylchitotetraoside hydrolase
• Host Species: Mouse
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Gene ID (Entrez): 1118
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized