Invitrogen™ CHMP1A Polyclonal Antibody

Catalog No.	Quantity
PIPA588181	100 μL

Catalog No. PIPA588181 Supplier Invitrogen™ Supplier No. PA588181

Description

Rabbit Polyclonal Antibody

Immunogen sequence: MDDTLFQLKF TAKQLEKLAK KAEKDSKAEQ AKVKKALLQK NVECARVYAE NAIRKKNEGV NWLRMASRVD AVASKVQTAV TMKGVTKNMA QVTKALDKAL STMDLQKVSS VMDRFEQQVQ NLDVHTSVME DSMSSATTLT TPQEQVDSLI MQIAEENGLE VLDQLSQLPE GASAVGESSV RSQEDQLSRR LAALRN; Positive Samples: 293T, LO2, HT-29, 22RV1, Mouse heart, Mouse kidney; Cellular Location: Cytoplasm, Endosome membrane, Nucleus matrix, Peripheral membrane protein.

Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I, -II and -III complexes. ESCRT- III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. May also be involved in chromosome condensation. Targets the Polycomb group (PcG) protein BMI1/PCGF4 to regions of condensed chromatin. May play a role in stable cell cycle progression and in PcG gene silencing.

Specifications

• Antigen: CHMP1A
• Applications: ELISA, Western Blot
• Classification: Polyclonal
• Concentration: 2.15 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene: CHMP1A
• Gene Accession No.: Q921W0, Q9HD42
• Gene Alias: 2900018H07Rik; charged multivesicular body protein 1/chromatin modifying protein 1; charged multivesicular body protein 1a; CHMP1; CHMP1A; chromatin modifying protein 1A; chromatin-modifying protein 1a; hVps46-1; KIAA0047; PCH8; PCOLN3; procollagen (type III) N-endopeptidase; protease, metallo, 1, 33kD; PRSM1; Vacuolar protein sorting-associated protein 46-1; Vps46-1; VPS46A
• Gene Symbols: CHMP1A
• Host Species: Rabbit
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-196 of human CHMP1A (NP_0027592).
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 234852, 5119
• Target Species: Human, Mouse
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG