Invitrogen™ CHMP3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA553364

Catalog No. PIPA553364

Description

Immunogen sequence: AMQSLVKIPE IQATMRELSK EMMKAGIIEE MLEDTFESMD DQEEMEEEAE MEIDRILFEI TAGALGKAPS KVTDALPEPE PPGAMAASED EEEEEEALEA MQSRLATLR Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 95%.

Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Selectively binds to phosphatidylinositol 3,5-bisphosphate PtdIns(3,5)P2 and PtdIns(3,4)P2 in preference to other phosphoinositides tested. Involved in late stages of cytokinesis. Plays a role in endosomal sorting/trafficking of EGF receptor. Isoform 2 prevents stress- mediated cell death and accumulation of reactive oxygen species when expressed in yeast cells.

Specifications

• Antigen: CHMP3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CHMP3
• Gene Alias: 25.1; 25.1 protein; 4921505F14Rik; 9130011K15Rik; CGI149; CGI-149; CGI-49; Charged multivesicular body protein 3; CHMP family, member 3; CHMP3; Chromatin-modifying protein 3; D6Ertd286e; hVps24; NEDF; Neuroendocrine differentiation factor; rVps24p; vacuolar protein sorting 24; vacuolar protein sorting 24 homolog; vacuolar protein sorting-associated protein 24; vacuolar protein-sorting-associated protein 24; Vps24; Vps24p protein
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 51652
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9Y3E7
• Gene Symbols: CHMP3
• Immunogen: Recombinant protein corresponding to Human CHMP3. Recombinant protein control fragment (Product #RP-91655).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG