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Invitrogen™ CHMP4B Polyclonal Antibody
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Catalog No. PIPA5121094
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100 μL
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PIPA5121094 100 μL
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Catalog No. PIPA5121094 Supplier Invitrogen™ Supplier No. PA5121094
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Description

Rabbit Polyclonal Antibody

Positive test controls include: HeLa, U-251MG, Mouse spleen, Rat heart. The target is usually found in the following locations: Cytoplasm, Late endosome membrane, Peripheral membrane protein, cytosol. Immunogen sequence: MSVFGKLFGA GGGKAGKGGP TPQEAIQRLR DTEEMLSKKQ EFLEKKIEQE LTAAKKHGTK NKRAALQALK RKKRYEKQLA QIDGTLSTIE FQREALENAN TNTEVLKNMG YAAKAMKAAH DNMDIDKVDE LMQDIADQQE LAEEISTAIS KPVGFGEEFD EDELMAELEE LEQEELDKNL LEISGPETVP LPNVPSIALP SKPAKKKEEE DDDMKELENW AGSM.

CHMP4B is a member of the chromatin-modifying protein/charged multivesicular body protein (CHMP) protein family. The protein is part of the endosomal sorting complex required for transport (ESCRT) complex III (ESCRT-III), which functions in the sorting of endocytosed cell-surface receptors into multivesicular endosomes. The ESCRT machinery also functions in the final abscisson stage of cytokinesis and in the budding of enveloped viruses such as HIV-1. The three proteins of the CHMP4 subfamily interact with programmed cell death 6 interacting protein (PDCD6IP, also known as ALIX), which also functions in the ESCRT pathway. The CHMP4 proteins assemble into membrane-attached 5-nm filaments that form circular scaffolds and promote or stabilize outward budding. These polymers are proposed to help generate the luminal vesicles of multivesicular bodies.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CHMP4B
Applications ELISA, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1.59 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene CHMP4B
Gene Accession No. Q9D8B3, Q9H444
Gene Alias 2010012F05Rik; C20orf178; C76846; charged multivesicular body protein 4b; CHMP4A; CHMP4B; chromatin modifying protein 4B; chromatin-modifying protein 4b; CTPP3; CTRCT31; dJ553F4.4; hSnf7-2; hVps32-2; RGD1309846; RGD1565889; Shax1; SNF7; SNF7 homolog associated with Alix 1; Snf7 homologue associated with Alix 1; Snf7-2; Vacuolar protein sorting-associated protein 32-2; vacuolar protein-sorting-associated protein 32-2; Vps32-2; VPS32B
Gene Symbols CHMP4B
Host Species Rabbit
Immunogen Recombinant Protein (or fragment).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100359642, 128866, 75608
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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