Invitrogen™ Cholera Toxin beta Monoclonal Antibody (A68G)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA518189

Catalog No. PIMA518189

Description

This antibody reacts with the B subunit of intact cholera toxin. Purity is >90%. Recommended pairs for ELISA: MA5-18189 (capture) and MA5-18188 or MA5-18190 (conjugated, detection).

Cholera toxin (sometimes abbreviated to CTX, Ctx, or CT) is a protein complex secreted by the bacterium Vibrio cholerae. CTX is the causative agent of cholera infection. The alpha subunit contains two chains, A1 and A2, linked by a disulfide bridge. The alpha subunit activates the adenylate cyclase enzyme in cells of the intestinal mucosa leading to increased levels of intracellular cAMP. The beta subunit of cholera toxin binds to a GM1-ganglioside receptor which is widely accepted to initiate toxin action by triggering uptake and delivery of the toxin alpha subunit into cells. The holotoxin consists of a pentameric ring of beta subunits whose central pore is occupied by the alpha subunit.

Specifications

• Antigen: Cholera Toxin beta
• Classification: Monoclonal
• Concentration: 100 μg/mL
• Formulation: PBS with 0.1% sodium azide; pH 7.2
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Target Species: Bacteria
• Product Type: Antibody
• Isotype: IgG1

• Applications: ELISA
• Clone: A68G
• Conjugate: Unconjugated
• Gene Alias: CTB; CTX; VC1456
• Immunogen: Cholera toxin native protein.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Content And Storage: 4°C
• Form: Liquid