Chorionic Gonadotropin beta Chain (HCG beta) Mouse anti-Human, Clone: HCGb/211, Novus Biologicals™

Mouse Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
NBP247732B	Novus Biologicals NBP2477320.2MG	0.2 mg

Description

Chorionic Gonadotropin beta Chain (hCG beta) Monoclonal specifically detects Chorionic Gonadotropin beta Chain (hCG beta) in Human samples. It is validated for Immunohistochemistry, Immunohistochemistry-Frozen.

Specifications

• Antigen: Chorionic Gonadotropin beta Chain (HCG beta)
• Concentration: 1.0 mg/mL
• Applications: Immunohistochemistry (Frozen)
• Conjugate: Unconjugated
• Host Species: Mouse
• Research Discipline: Cancer
• Formulation: PBS with No Preservative
• Gene ID (Entrez): 1082
• Immunogen: Purified human HCG-beta
• Primary or Secondary: Primary
• Content And Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Molecular Weight of Antigen: 22 kDa

• Clone: HCGb/211
• Dilution: Immunohistochemistry-Frozen : 0.5 - 1.0 ug/ml
• Classification: Monoclonal
• Form: Purified
• Regulatory Status: RUO
• Target Species: Human
• Gene Alias: CGB3choriogonadotropin subunit beta, CGB5, CGB7, CGB8, CG-beta, Chorionic gonadotrophin chain beta, chorionic gonadotropin beta 3 subunit, chorionic gonadotropin beta chain, chorionic gonadotropin beta subunit, chorionic gonadotropin, beta polypeptide, hCGB
• Gene Symbols: CGB
• Isotype: IgG1
• Purification Method: Protein A or G purified
• Test Specificity: This MAb reacts with a protein of 22kDa, identified as beta sub-unit of HCG. It does not cross react with the alpha sub-unit. HCG is a glycoprotein, which is secreted in large quantities by normal trophoblasts. It is present only in trace amounts in non-pregnant urine and sera but rises sharply during pregnancy. HCG is composed of two non-identical, non-covalently linked polypeptide chains designated as the alpha and beta subunits. The alpha subunit is identical to that of thyroid stimulating hormone (TSH), follicle stimulating hormone (FSH), and luteinizing hormone (LH). hCG MAb detects cells and tumors of trophoblastic origin such as choriocarcinoma. Large cell carcinoma and adenocarcinoma of the lung demonstrate anti-hCG positivity in 90% and 60% of cases respectively. 20% of lung squamous cell carcinomas are positive. hCG expression by non-trophoblastic tumors may indicate aggressive behavior.