Invitrogen™ CHRFAM7A Polyclonal Antibody

Catalog No.	Quantity
PIPA588655	100 μL

Catalog No. PIPA588655 Supplier Invitrogen™ Supplier No. PA588655

Description

Rabbit Polyclonal Antibody

Immunogen sequence: MQKYCIYQHF QFQLLIQHLW IAANCDIADE RFDATFHTNV LVNSSGHCQY LPPGIFKSSC YIDVRWFPFD VQHCKLKFGS WSYGGWSLDL QMQEADISGY IPNGEWDLVG IPGKRSERFY ECCKEPYPDV TFTVTMRRRT LYYGLNLLIP; Positive Samples: NIH/3T3, Mouse brain, Rat brain; Cellular Location: Membrane, Multi-pass membrane protein.

The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The family member CHRNA7, which is located on chromosome 15 in a region associated with several neuropsychiatric disorders, is partially duplicated and forms a hybrid with a novel gene from the family with sequence similarity 7 (FAM7A). Alternative splicing has been observed, and two variants exist, for this hybrid gene. The N-terminally truncated products predicted by the largest open reading frames for each variant would lack the majority of the neurotransmitter-gated ion-channel ligand binding domain but retain the transmembrane region that forms the ion channel. Although current evidence supports transcription of this hybrid gene, translation of the nicotinic acetylcholine receptor-like protein-encoding open reading frames has not been confirmed.

Specifications

• Antigen: CHRFAM7A
• Applications: ELISA, Western Blot
• Classification: Polyclonal
• Concentration: 0.35 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene: CHRFAM7A
• Gene Accession No.: Q494W8
• Gene Alias: alpha 7 neuronal nicotinic acetylcholine receptor-FAM7A hybrid; alpha-7 nicotinic cholinergic receptor subunit; CHRFAM7A; CHRNA7; CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion; CHRNA7 (cholinergic receptor, nicotinic, alpha polypeptide 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion; CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion; CHRNA7-DR1; CHRNA7-FAM7A fusion protein; D-10; NACHRA7; Neuronal acetylcholine receptor subunit alpha-7
• Gene Symbols: CHRFAM7A
• Host Species: Rabbit
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human CHRFAM7A (NP_6475361).
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 89832
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG