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Invitrogen™ CHRM2 Polyclonal Antibody
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Catalog No. PIPA590608
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100 μL
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PIPA590608 100 μL
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Catalog No. PIPA590608 Supplier Invitrogen™ Supplier No. PA590608
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: HISRASKSRI KKDKKEPVAN QDPVSPSLVQ GRIVKPNNNN MPSSDDGLEH NKIQNGKAPR DPVTENCVQG EEKESSNDST SVSAVASNMR DDEITQDENT VSTSLGHSKD ENSKQTCIRI GTKTPKSDSC TPTNTTVEVV GSSGQNGDEK QNIVARKIVK MTKQPAKKKP PPSREKKVTR T; Positive Samples: SH-SY5Y, HepG2; Cellular Location: Cell junction, Cell membrane, Multi-pass membrane protein, postsynaptic cell membrane, synapse.

Muscarinic cholinergic receptor 2 (CHRM2) is an Acetylcholine Receptor has been suggested to function as a presynaptic autoreceptor that inhibits acetylcholine release. The M2 receptor has also been suggested to mediate smooth muscle contractility. Alzheimer's disease (AD) involves selective loss of M2 subtype receptors in cortical and hippocampal regions of the human brain. Increase in M2 receptor heterozygosity has been associated with depression in women. The M2 receptor has been reported to be expressed in various regions of the brain including the cerebellum, cerebral cortex, hippocampus, medulla, striatum, and thalamus, and in lung and prostate.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CHRM2
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.99 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene CHRM2
Gene Accession No. P08172
Gene Alias 7TM receptor; acetylcholine receptor; acetylcholine receptor, muscarinic 2; AChR M2; AChR-M2; Acm2; cardiac muscarinic acetylcholine receptor; cholinergic receptor; cholinergic receptor muscarinic 2; cholinergic receptor, muscarinic 2; cholinergic receptor, muscarinic 2, cardiac; cholinergic receptor, muscarinic 2, isoform a; Chrm2; Chrm-2; FLJ43243; HM2; M2; M2 muscarinic acetylcholine receptor; m2AChR; M2-mAChR; MGC120006; MGC120007; muscarinic acetylcholine receptor 2; muscarinic acetylcholine receptor m2; muscarinic M2 receptor; muscarinic receptor m2; unnamed protein product
Gene Symbols CHRM2
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 208-388 of human Muscarinic AChR M2 (ACM2) (NP_0010066291).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1129
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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