Invitrogen™ CHRNG Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA531170

Catalog No. PIPA531170

Description

Recommended positive controls: 293T, A431. Predicted reactivity: Mouse (82%), Rat (82%), Bovine (88%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The mammalian muscle-type acetylcholine receptor is a transmembrane pentameric glycoprotein with two alpha subunits, one beta, one delta, and one epsilon (in adult skeletal muscle) or gamma (in fetal and denervated muscle) subunit. This gene, which encodes the gamma subunit, is expressed prior to the thirty-third week of gestation in humans. The gamma subunit of the acetylcholine receptor plays a role in neuromuscular organogenesis and ligand binding and disruption of gamma subunit expression prevents the correct localization of the receptor in cell membranes. Mutations in this gene cause Escobar syndrome and a lethal form of multiple pterygium syndrome. Muscle-type acetylcholine receptor is the major antigen in the autoimmune disease myasthenia gravis.

Specifications

• Antigen: CHRNG
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CHRNG
• Gene Alias: acetylcholine receptor; Acetylcholine receptor subunit gamma; acetylcholine receptor, muscle, gamma subunit; acetylcholine receptor, nicotinic, gamma (muscle); AChR gamma subunit; Achr-3; ACHRG; Acrg; cholinergic receptor; cholinergic receptor nicotinic gamma subunit; cholinergic receptor, nicotinic gamma; cholinergic receptor, nicotinic, gamma (muscle); cholinergic receptor, nicotinic, gamma polypeptide; Chrng; chrng variant N1; chrng variant N2; nicotinic acetylcholine receptor gamma subunit
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1146
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: P07510
• Gene Symbols: CHRNG
• Immunogen: Recombinant protein encompassing a sequence within the center region of human AChR gamma. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG