Invitrogen™ CHST1 Monoclonal Antibody (543128)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA524243

Catalog No. PIMA524243

Description

In direct ELISAs, approximately 25-100% cross-reactivity with recombinant mouse CHST1 and no cross-reactivity with recombinant human CHST2, 3, 4, 5, 6, 7, 10, and 14 is observed. Reconstitute in sterile PBS to a final concentration of 0.5 mg/mL.

Carbohydrate sulfotransferase 1 (CHST1), also referred to as KSGal6ST or KSST, is a keratan sulfate sulfotransferase. It is predominantly expressed in brain and skeletal muscle and localizes to the trans-Golgi network. CHST1 is responsible for mediating the sulfation of keratan in the cornea, which is important in maintaining corneal transparency. In particular, CHST1 catalyzes the transfer of sulfate groups from 3'-phosphoadenosine 5'-phosphosulfate to position six of internal or terminal galactose residues (preferentially the residues adjacent to sulfated GlcNAc) on growing keratan sulfate chains. CHST1 also contributes to the generation of L-selectin ligands. Mutations in the CHST1 gene may play a role in macular corneal dystrophy (MCD).

Specifications

• Antigen: CHST1
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: O43916
• Gene Symbols: CHST1
• Immunogen: CHO-derived recombinant human Carbohydrate Sulfotransferase 1/CHST1 Arg24-Ser411.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunoprecipitation, Neutralization
• Clone: 543128
• Conjugate: Unconjugated
• Gene: CHST1
• Gene Alias: 2610008E20Rik; AW125896; C6ST; carbohydrate (chondroitin 6/keratan) sulfotransferase 1; carbohydrate (keratan sulfate Gal-6) sulfotransferase 1; carbohydrate sulfotransferase 1; chst1; Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 1; Gst1; GST-1; hypothetical protein LOC445124; keratan sulfate Gal-6 sulfotransferase; Keratan sulfotransferase; KS6ST; KSGal6ST; KSST; N-acetylglucosamine-6-O-sulfotransferase 1; sulfo1; sulfotransferase1; zgc:100904; zgc:100904 protein
• Host Species: Mouse
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Gene ID (Entrez): 8534
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized