Invitrogen™ CHST1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA542740

Catalog No. PIPA542740

Description

Peptide sequence: SFVGQLFNQH LDVFYLFEPL YHVQNTLIPR FTQGKSPADR RVMLGASRDL Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 100%.

Carbohydrate sulfotransferase 1 (CHST1), also referred to as KSGal6ST or KSST, is a keratan sulfate sulfotransferase. It is predominantly expressed in brain and skeletal muscle and localizes to the trans-Golgi network. CHST1 is responsible for mediating the sulfation of keratan in the cornea, which is important in maintaining corneal transparency. In particular, CHST1 catalyzes the transfer of sulfate groups from 3'-phosphoadenosine 5'-phosphosulfate to position six of internal or terminal galactose residues (preferentially the residues adjacent to sulfated GlcNAc) on growing keratan sulfate chains. CHST1 also contributes to the generation of L-selectin ligands. Mutations in the CHST1 gene may play a role in macular corneal dystrophy (MCD).

Specifications

• Antigen: CHST1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CHST1
• Gene Alias: 2610008E20Rik; AW125896; C6ST; carbohydrate (chondroitin 6/keratan) sulfotransferase 1; carbohydrate (keratan sulfate Gal-6) sulfotransferase 1; carbohydrate sulfotransferase 1; chst1; Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 1; Gst1; GST-1; hypothetical protein LOC445124; keratan sulfate Gal-6 sulfotransferase; Keratan sulfotransferase; KS6ST; KSGal6ST; KSST; N-acetylglucosamine-6-O-sulfotransferase 1; sulfo1; sulfotransferase1; zgc:100904; zgc:100904 protein
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 8534
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Immunohistochemistry, Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene Accession No.: O43916
• Gene Symbols: CHST1
• Immunogen: Synthetic peptide directed towards the N-terminal of human CHST1 (aa 74-123).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG