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Invitrogen™ CHST1 Polyclonal Antibody
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Catalog No. PIPA588951
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100 μL
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PIPA588951 100 μL
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Catalog No. PIPA588951 Supplier Invitrogen™ Supplier No. PA588951
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: HILILATTRS GSSFVGQLFN QHLDVFYLFE PLYHVQNTLI PRFTQGKSPA DRRVMLGASR DLLRSLYDCD LYFLENYIKP PPVNHTTDRI FRRGASRVLC SRPVCDPPGP ADLVLEEGDC VRKCGLLNLT VAAEACRERS HVAIKTVRVP EVNDLRALVE DPRLNLKVIQ LVRDPRGILA SRSETFRDTY RLWRLWYGTG RKPYNLDVTQ LTTVCEDFSN SVSTGLMRPP WLKGKYMLVR YEDLARNPMK KTEEIYGFLG IPLDSHVARW IQNNTRGDPT LGKHKYGTVR NSAATAEKWR FRLSYDIVAF AQNACQQVLA QLGYKIAASE EELKNPSVSL VEERDFRPFS; Positive Samples: Mouse liver, Mouse kidney, Rat brain; Cellular Location: Golgi apparatus membrane, Single-pass type II membrane protein.

Carbohydrate sulfotransferase 1 (CHST1), also referred to as KSGal6ST or KSST, is a keratan sulfate sulfotransferase. It is predominantly expressed in brain and skeletal muscle and localizes to the trans-Golgi network. CHST1 is responsible for mediating the sulfation of keratan in the cornea, which is important in maintaining corneal transparency. In particular, CHST1 catalyzes the transfer of sulfate groups from 3'-phosphoadenosine 5'-phosphosulfate to position six of internal or terminal galactose residues (preferentially the residues adjacent to sulfated GlcNAc) on growing keratan sulfate chains. CHST1 also contributes to the generation of L-selectin ligands. Mutations in the CHST1 gene may play a role in macular corneal dystrophy (MCD).
TRUSTED_SUSTAINABILITY

Specifications

Antigen CHST1
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 2.39 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene CHST1
Gene Accession No. Q5RJQ0, Q9EQC0
Gene Alias 2610008E20Rik; AW125896; C6ST; carbohydrate (chondroitin 6/keratan) sulfotransferase 1; carbohydrate (keratan sulfate Gal-6) sulfotransferase 1; carbohydrate sulfotransferase 1; chst1; Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 1; Gst1; GST-1; hypothetical protein LOC445124; keratan sulfate Gal-6 sulfotransferase; Keratan sulfotransferase; KS6ST; KSGal6ST; KSST; N-acetylglucosamine-6-O-sulfotransferase 1; sulfo1; sulfotransferase1; zgc:100904; zgc:100904 protein
Gene Symbols CHST1
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 62-411 of human CHST1 (NP_0036451).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 295934, 76969
Target Species Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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