Invitrogen™ CD66e/CD3 (Cibisatamab Biosimilar) Recombinant Human Monoclonal Antibody

Catalog No.	Quantity
PIMA542186	100 μg

Catalog No. PIMA542186 Supplier Invitrogen™ Supplier No. MA542186

Description

Human Recombinant Monoclonal Antibody

Endotoxin level <0.01EU/μg by LAL method Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 °C for one week. Store at -20 to -80 °C for twelve months from the date of receipt. This product is a Humanized mouse antibody.

CEA (Carcinoembryonic Antigen, CD66e) is a glycoprotein normally produced during fetal development in the gastrointestinal tract and re-expressed at high levels in many cancers, particularly colorectal and other adenocarcinomas. It belongs to the immunoglobulin superfamily and contains one variable-like N domain and six constant-like domains (A1-A3, B1-B3). CEA is widely used as a tumor marker, especially for adenocarcinomas of the digestive tract. It is helpful in identifying the origin of metastatic adenocarcinomas and in distinguishing pulmonary adenocarcinoma (often CEA-positive) from pleural mesothelioma (rarely CEA-positive). The CEA gene family, including CEA cell adhesion molecules and pregnancy-specific glycoproteins, is clustered on chromosome 19 and includes several pseudogenes. Originally identified as a biliary glycoprotein, CEA is now recognized as a cell adhesion molecule expressed on epithelial, endothelial, and some immune cells. It mediates homophilic and heterophilic cell adhesion and has been implicated in tissue organization, angiogenesis, apoptosis, metastasis, tumor progression, and modulation of immune responses. Multiple transcript variants exist, though not all are fully characterized.CD3 is a multi-subunit complex (gamma, delta, epsilon, and zeta) essential for assembly and surface expression of the T cell receptor (TCR). These immunoglobulin superfamily proteins are encoded by closely linked genes on chromosome 11 and are expressed on thymocytes and all mature T cells, but not on B or NK cells. CD3 transduces antigen-recognition signals into T cells through tyrosine-based motifs in its cytoplasmic tails. TCR engagement activates signaling pathways that drive T cell activation, proliferation, survival, or growth arrest. CD3 defects cause immunodeficiency, underscoring its critical role in immune regulation.

Specifications

• Antigen: CD66e/CD3 (Cibisatamab Biosimilar)
• Applications: ELISA, SDS-Page
• Classification: Recombinant Monoclonal
• Concentration: 2.54 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with no preservative; pH 7.4
• Gene Alias: CEA TCB; RG-7802; RO-6958688
• Host Species: Human
• Immunogen: Human CD3E/CEACAM5.
• Purification Method: Protein A/G
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1 κ, IgG1 λ
• Target Molecule: Chemical

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov