Invitrogen™ Cibisatamab Humanized Recombinant Human Monoclonal Antibody

Human Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA542186

Catalog No. PIMA542186

Description

Endotoxin level < 0.01EU/μg by LAL method Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 °C for one week. Store at -20 to -80 °C for twelve months from the date of receipt.

Cibisatamab (CEA-TCB) is a T cell bispecific antibody that binds carcinoembryonic antigen (CEA) on cancer cells and CD3 on T cells. Cibisatamab has a single CD3epsilon chain binding site and two CEA binding sites on T cells (it regulates the binding affinity to cancer cells with high expression of CEA on the cell surface). This avoids targeting healthy epithelial cells with low CEA expression levels. T cell activation, cytokine secretion and release of cytotoxic particles are triggered by binding to CEA on the surface of cancer cells and CD3 on T cells.

Specifications

• Antigen: Cibisatamab Humanized
• Classification: Recombinant Monoclonal
• Conjugate: Unconjugated
• Gene Alias: CEA TCB; RG-7802; RO-6958688
• Immunogen: Human CD3E/CEACAM5.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid
• Target Molecule: Chemical

• Applications: ELISA, SDS-Page
• Concentration: 2.54 mg/mL
• Formulation: PBS with no preservative; pH 7.4
• Host Species: Human
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1 κ, IgG1 λ

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov