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Invitrogen™ CIP2A Monoclonal Antibody (2G10)
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Catalog No. MA146001
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100 μL
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MA146001 100 μL
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Catalog No. MA146001 Supplier Invitrogen™ Supplier No. MA146001
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Description

Mouse Monoclonal Antibody

Suggested positive control: Hela whole cell extract, antigen standard for KIAA1524 (transient overexpression lysate).

Inhibition of protein phosphatase 2A (PP2A) activity has been identified as a prerequisite for the transformation of human cells. The protein, designated Cancerous Inhibitor of PP2A (CIP2A), interacts directly with the oncogenic transcription factor c-Myc, inhibits PP2A activity toward c-Myc serine 62 (S62), and thereby prevents c-Myc proteolytic degradation. In addition to its function in c-Myc stabilization, CIP2A promotes anchorage-independent cell growth and in vivo tumor formation. The oncogenic activity of CIP2A is demonstrated by transformation of human cells by overexpression of CIP2A. Importantly, CIP2A is overexpressed in two common human malignancies, head and neck squamous cell carcinoma (HNSCC) and colon cancer.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CIP2A
Applications Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 2G10
Concentration 1.0 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene Cip2a
Gene Accession No. Q8BWY9, Q8TCG1
Gene Alias AA408511; AU018569; C330027C09Rik; Cancerous inhibitor of PP2A; cancerous inhibitor of protein phosphatase 2A; Cip2a; Kiaa1524; p90; p90 autoantigen; p90 autoantigen homolog; Protein CIP2A; RGD1310335; RIKEN cDNA C330027C09 gene; similar to RIKEN cDNA C330027C09
Gene Symbols Cip2a
Host Species Mouse
Immunogen A synthetic peptide made to a C-terminal portion of the human CIP2A protein.
Purification Method Protein G
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 224171, 360711, 57650
Target Species Human, Mouse, Rat, Monkey
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG2b κ
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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