Invitrogen™ CIP2A Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA579553

Catalog No. PIPA579553

Description

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: Mouse Testis Tissue, HELA whole cell.

Inhibition of protein phosphatase 2A (PP2A) activity has been identified as a prerequisite for the transformation of human cells. The protein, designated Cancerous Inhibitor of PP2A (CIP2A), interacts directly with the oncogenic transcription factor c-Myc, inhibits PP2A activity toward c-Myc serine 62 (S62), and thereby prevents c-Myc proteolytic degradation. In addition to its function in c-Myc stabilization, CIP2A promotes anchorage-independent cell growth and in vivo tumor formation. The oncogenic activity of CIP2A is demonstrated by transformation of human cells by overexpression of CIP2A. Importantly, CIP2A is overexpressed in two common human malignancies, head and neck squamous cell carcinoma (HNSCC) and colon cancer.

Specifications

• Antigen: CIP2A
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Cip2a
• Gene Alias: AA408511; AU018569; C330027C09Rik; Cancerous inhibitor of PP2A; cancerous inhibitor of protein phosphatase 2A; Cip2a; Kiaa1524; p90; p90 autoantigen; p90 autoantigen homolog; Protein CIP2A; RGD1310335; RIKEN cDNA C330027C09 gene; similar to RIKEN cDNA C330027C09
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 224171, 57650
• Content And Storage: -20°C
• Form: Lyophilized

• Applications: Western Blot, Immunocytochemistry
• Concentration: 500 μg/mL
• Formulation: PBS with 5mg BSA and 0.05mg sodium azide
• Gene Accession No.: Q8BWY9, Q8TCG1
• Gene Symbols: Cip2a
• Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human KIAA1524 (854-889aa EVQKAQLEGRLEEKESLVKLQQEELNKHSHMIAMIH).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG