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Invitrogen™ CIP2A Polyclonal Antibody
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Catalog No. PIPA588456
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100 μL
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PIPA588456 100 μL
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Catalog No. PIPA588456 Supplier Invitrogen™ Supplier No. PA588456
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: EVERKNEELS VLLKAQQVES ERAQSDIEHL FQHNRKLESV AEEHEILTKS YMELLQRNES TEKKNKDLQI TCDSLNKQIE TVKKLNESLK EQNEKSIAQL IEKEEQRKEV QNQLVDREHK LANLHQKTKV QEEKIKTLQK EREDKEETID ILRKELSRTE QIRKELSIKA SSLEVQKAQL EGRLEEKESL VKLQQEELNK HSHMIAMIHS LSGGKINPET VNLSI; Positive Samples: HepG2, U-87MG, MCF7, HeLa, A375, Rat testis; Cellular Location: Cytoplasm, Membrane, Single-pass membrane protein.

Inhibition of protein phosphatase 2A (PP2A) activity has been identified as a prerequisite for the transformation of human cells. The protein, designated Cancerous Inhibitor of PP2A (CIP2A), interacts directly with the oncogenic transcription factor c-Myc, inhibits PP2A activity toward c-Myc serine 62 (S62), and thereby prevents c-Myc proteolytic degradation. In addition to its function in c-Myc stabilization, CIP2A promotes anchorage-independent cell growth and in vivo tumor formation. The oncogenic activity of CIP2A is demonstrated by transformation of human cells by overexpression of CIP2A. Importantly, CIP2A is overexpressed in two common human malignancies, head and neck squamous cell carcinoma (HNSCC) and colon cancer.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CIP2A
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.27 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene Cip2a
Gene Accession No. Q8BWY9, Q8TCG1
Gene Alias AA408511; AU018569; C330027C09Rik; Cancerous inhibitor of PP2A; cancerous inhibitor of protein phosphatase 2A; Cip2a; Kiaa1524; p90; p90 autoantigen; p90 autoantigen homolog; Protein CIP2A; RGD1310335; RIKEN cDNA C330027C09 gene; similar to RIKEN cDNA C330027C09
Gene Symbols Cip2a
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 681-905 of human KIAA1524 (NP_0659412).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 224171, 360711, 57650
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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