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CIP2A Rabbit anti-Human, Mouse, Rat, Polyclonal, Bethyl Laboratories
SDP

Rabbit Polyclonal Antibody

Supplier:  Bethyl Laboratories, Inc A301454A

Encompass_Preferred

Catalog No. 50-156-0433


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Description

Description

The recommended shelf life for this product is 1 year from date of receipt. Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

Inhibition of protein phosphatase 2A (PP2A) activity has been identified as a prerequisite for the transformation of human cells. The protein, designated Cancerous Inhibitor of PP2A (CIP2A), interacts directly with the oncogenic transcription factor c-Myc, inhibits PP2A activity toward c-Myc serine 62 (S62), and thereby prevents c-Myc proteolytic degradation. In addition to its function in c-Myc stabilization, CIP2A promotes anchorage-independent cell growth and in vivo tumor formation. The oncogenic activity of CIP2A is demonstrated by transformation of human cells by overexpression of CIP2A. Importantly, CIP2A is overexpressed in two common human maligcies, head and neck squamous cell carcinoma (HNSCC) and colon cancer.
Specifications

Specifications

CIP2A
Polyclonal
Unconjugated
CIP2A
Cancerous Inhibitor of Protein Phosphatase 2A , p90
Rabbit
Antigen affinity chromatography
RUO
224171, 360711, 57650
4° C
Liquid
Immunohistochemistry, Immunoprecipitation, Western Blot
0.2 mg/ml
TBS with 0.1% BSA and 0.09% sodium azide
Q8BWY9, Q8TCG1
Cip2a
Between 853 and 903
100 μL
Primary
Human, Mouse, Rat
Antibody
IgG
SDS
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