CIP2A Rabbit anti-Human, Mouse, Rat, Polyclonal, Bethyl Laboratories

Catalog No.	Quantity
50-156-0433	100 μL

Catalog No. 50-156-0433

Supplier: Bethyl Laboratories, Inc A301454A

Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt. Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

Inhibition of protein phosphatase 2A (PP2A) activity has been identified as a prerequisite for the transformation of human cells. The protein, designated Cancerous Inhibitor of PP2A (CIP2A), interacts directly with the oncogenic transcription factor c-Myc, inhibits PP2A activity toward c-Myc serine 62 (S62), and thereby prevents c-Myc proteolytic degradation. In addition to its function in c-Myc stabilization, CIP2A promotes anchorage-independent cell growth and in vivo tumor formation. The oncogenic activity of CIP2A is demonstrated by transformation of human cells by overexpression of CIP2A. Importantly, CIP2A is overexpressed in two common human maligcies, head and neck squamous cell carcinoma (HNSCC) and colon cancer.

Specifications

• Antigen: CIP2A
• Applications: Immunohistochemistry, Immunoprecipitation, Western Blot
• Classification: Polyclonal
• Concentration: 0.2 mg/ml
• Conjugate: Unconjugated
• Formulation: TBS with 0.1% BSA and 0.09% sodium azide
• Gene: CIP2A
• Gene Accession No.: Q8BWY9, Q8TCG1
• Gene Alias: Cancerous Inhibitor of Protein Phosphatase 2A , p90
• Gene Symbols: Cip2a
• Host Species: Rabbit
• Immunogen: Between 853 and 903
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 224171, 360711, 57650
• Target Species: Human, Mouse, Rat
• Content And Storage: 4° C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG